PUBLICATIONS

Here is a list of selected publications from the BRAIN team and collaborators, highlighting the use of preclinical imaging & corroborative methods at KCL:

2022

Bogado Lopes, J., Senko, A. N., Bahnsen, K., Geisler, D., Kim, E., Bernanos, M., Cash, D., Ehrlich, S, Vernon, A. C., Kempermann, G. (2022) Individual behavioral trajectories shape whole-brain connectivity in mice.

MacNicol, E., Wright, P., Kim, E., Brusini, I., Esteban, O., Simmons, C., Turkheimer, F.E., & Cash, D. (2022) Age-Specific Adult Rat Brain MRI Templates and Tissue Probability Maps. Front Neuroinform, 15, 669049. doi: 10.3389/fninf.2021.669049

Kiemes, A, Navacerrada, MES, Kim, E, Randall, K, Simmons, C, Gonzalez, LR, Petrinovic, MM, Lythgoe, DJ, Rotaru, D, Di Censo, D, Hirshler, L, Barbier, EL, Vernon, AC, Stone, JM, Davies, C, Cash, D, & Modinos, G (2022) Erbb4 deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypes. bioRxiv 2022.03.07.483347. doi: 10.1101/2022.03.07.483347 

Brusini, I, MacNicol, E, Kim, E, Smedby, Ö, Wang, C, Westman, E, Veronese, M, Turkheimer, F, & Cash, D (2022) MRI-derived brain age as a biomarker of ageing in rats: validation using a healthy lifestyle intervention. Neurobiol Aging 109: 204-215. doi: 10.1016/j.neurobiolaging.2021.10.004 

 

2021

Frison, M, Faccenda, D, Abeti, R, Rigon, M, Strobbe, D, England-Rendon, BS, Cash, D, Barnes, K, Sadeghian, M, Sajic, M, Wells, LA, Xia, D, Giunti, P, Smith, K, Mortiboys, H, Turkheimer, FE, & Campanella, M (2021) The translocator protein (TSPO) is prodromal to mitophagy loss in neurotoxicity. Mol Psychiatr 26:2721–273. doi: 10.1038/s41380-021-01050-z 

Gelegen, C, Cash, D, Ilic, K, Sander, M, Kim, E, Simmons, C, Bernanos, M, Lamma, J, Randall, K, Brown, J, Bognar, SK, Cooke, S, Chaudhury, KR, Ballard, C, Francis, P, & Rosenzweig, I (2021) Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder. bioRxiv 2021.05.26.445845. doi: 10.1101/2021.05.26.445845 

Wood, TC, Cash, D, MacNicol, E, Simmons, C, Kim, E, Lythgoe, DJ, Zelaya, F, & Turkheimer, F (2021) Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents. Wellcome Open Res 6:109. doi:10.12688/wellcomeopenres.16734.2 

Vicente-Rodríguez, M, Singh, N, Turkheimer, F, Peris-Yague, A, Randall, K, Veronese, M, Simmons, C, Haji-Dheere, AK, Bordoloi, J, Sander, K, Awais, RO, Årstad, E, Consortium, N, Cash, D, & Parker, CA (2021) Resolving the cellular specificity of TSPO imaging in a rat model of peripherally-induced neuroinflammation. Brain Behav Immun 96:154–167. doi: 10.1016/j.bbi.2021.05.025 

Kiemes, A, Gomes, FV, Cash, D, Uliana, DL, Simmons, C, Singh, N, Vernon, AC, Turkheimer, F, Davies, C, Stone, JM, Grace, AA, & Modinos, G (2021) GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia. Neuropsychopharmacol 47:687–695. doi: 10.1038/s41386-021-01213-0 

Barrett, RLC, Cash, D, Simmons, C, Kim, E, Wood, TC, Stones, R, Vernon, AC, Catani, M, & Dell’Acqua, F (2021) Tissue Optimisation Strategies for High Quality Ex Vivo Diffusion Imaging. bioRxiv 2021.12.13.472113. doi: 10.1101/2021.12.13.472113 

Kim, E, Di Censo, D, Baraldo, M, Simmons, C, Rosa, I, Randall, K, Ballard, C, Dickie, BR, Williams, SCR, Killick, R, & Cash, D (2021) In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease. Sci Rep 11: 12419. doi: 10.1038/s41598-021-91899-5 

Lin Z, Kim E, Ahmed M, Han G, Simmons C, Redhead Y, Bartlett J, Altamira LEP, Callaghan I, White MA, Singh N, Sawiak S, Spires-Jones T, Vernon AC, Coleman MP, Green J, Henstridge C, Davies JS, Cash D, Sreedharan J (2021) MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD. Brain Commun 3. doi:10.1093/braincomms/fcab114  

Mueller, FS, Scarborough, J, Schalbetter, SM, Richetto, J, Kim, E, Couch, A, Yee, Y, Lerch, JP, Vernon, AC, Weber-Stadlbauer, U, & Meyer, U (2021) Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation. Mol Psychiatr, 26:396–410. doi:10.1038/s41380-020-00952-8

2020

Basalay, MV, Wiart, M, Chauveau, F, Dumot, C, Leon, C, Amaz, C, Bolbos, R, Cash, D, Kim, E, Mechtouff, L, Cho, T-H, Nighoghossian, N, Davidson, SM, Ovize, M, & Yellon, DM (2020) Neuroprotection by remote ischemic conditioning in the setting of acute ischemic stroke: a preclinical two-centre study. Scientific Reports 10:e46-10. doi: 10.1038/s41598-020-74046-4 

Peris-Yague, A, Kiemes, A, Cash, D, Cotel, M-C, Singh, N, Vernon, AC, Modinos, G (2020) Region-specific and dose-specific effects of chronic haloperidol exposure on [3H]-flumazenil and [3H]-Ro15-4513 GABAA receptor binding sites in the rat brain. European Neuropsychopharmacology, 41:106-117. doi: 10.1016/j.euroneuro.2020.10.004 

Morgan CA, Mesquita M, Ashioti M, Beech JS, Williams SCR, Irving E, Cash D (2020) Late changes in blood–brain barrier permeability in a rat tMCAO model of stroke detected by gadolinium-enhanced MRI. Neurological Research 24:1–9. doi: 10.1080/01616412.2020.1786637

Mota F, Sementa T, Taddei C, Moses N, Bordoloi J, Hader S, Eykyn T, Cash D, Turkheimer F, Veronese M, Singh N (2020) Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission. Synapse 47:698–6. doi: 10.1002/syn.22151  

Polsek D, Cash D, Veronese M, Ilic K, Wood TC, Milosevic M, Kalanj-Bognar S, Morrell MJ, Williams SCR, Gajovic S, Leschziner GD, Mitrecic D, Rosenzweig I (2020) The Innate Immune Toll-Like Receptor-2 modulates the Depressogenic and Anorexiolytic Neuroinflammatory Response in Obstructive Sleep Apnoea.  Scientific Reports 10:404–413. doi: https://doi.org/10.1038/s41598-020-68299-2  

Wood TC, Edye ME, Harte MK, Neill JC, Prinssen EP, Vernon AC (2020) Preliminary evidence that maternal immune activation specifically increases diagonal domain volume in the rat brain during early postnatal development. 299:241–27. doi: 10.1101/432450

2019

Ashraf A, Michaelides C, Walker TA, Ekonomou A, Suessmilch M, Sriskanthanathan A, Abraha S, Parkes A, Parkes HG, Geraki K, So P-W (2019) Regional Distributions of Iron, Copper and Zinc and Their Relationships With Glia in a Normal Aging Mouse Model. FrontiAgNeurosci 11:165–16. doi: 10.3389/fnagi.2019.00351

Doostdar N, Kim E, Grayson B, Harte MK, Neill JC, Vernon AC (2019) Global brain volume reductions in a sub-chronic phencyclidine animal model for schizophrenia and their relationship to recognition memory. Journal of Psychopharmacology 33:1274–1287. doi: 10.1177/0269881119844196

Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodríguez M, Parker CA, Simmons C, Cash D, Richardson J, NIMA Consortium, Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH (2019) CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice. Brain 142:3243–3264. doi: 10.1093/brain/awz241

So P-W, Ekonomou A, Galley K, Brody L, Sahuri-Arisoylu M, Rattray I, Cash D& Bell J. (2019) Intraperitoneal Delivery of Acetate-Encapsulated Liposomal Nanoparticles for Neuroprotection of the Penumbra in a Rat Model of Ischemic Stroke. International Journal of Nanomedicine, 14:1979-1991.

White MA, Lin Z, Kim E, Henstridge CM, Pena Altamira E, Hunt CK, Burchill E, Callaghan I, Loreto A, Brown-Wright H, Mead R, Simmons C, Cash D, Coleman MP, Sreedharan J (2019) Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss. Acta Neuropathol Commun 7:166–16. doi: 10.1186/s40478-019-0800-9

2018

Duricki DA, Drndarski S, Bernanos M, Wood T, Bosch K, Chen Q, Shine HD, Simmons C, Williams SCR, McMahon SB, Begley DJ, Cash D, Moon LDF (2018) Stroke recovery in rats after 24h‐delayed, intramuscular neurotrophin‐3 infusion. Ann Neurol ana.25386–30. doi: 10.1002/ana.25386 

Horder J, Andersson M, Mendez MA, Singh N, Tangen Ä, Lundberg J, Gee A, Halldin C, Veronese M, Bölte S, Farde L, Sementa T, Cash D, Higgins K, Spain D, Turkheimer F, Mick I, Selvaraj S, Nutt DJ, Lingford-Hughes A, Howes OD, Murphy DG, Borg J (2018) GABAA receptor availability is not altered in adults with autism spectrum disorder or in mouse models. Sci Transl Med 10:eaam8434. doi: 10.1126/scitranslmed.aam8434

Singh N, Veronese M, O’Doherty J, Sementa T, Bongarzone S, Cash D, Simmons C, Arcolin M, Marsden PK, Gee A, Turkheimer FE (2018) Assessing the feasibility of intranasal radiotracer administration for in brain PET imaging. Nuclear Medicine and Biology 66:32–39. doi: 10.1016/j.nucmedbio.2018.08.005

 Stolp H.B., Ball G, So PW, Tournier JD, Jones M, Thornton C, Edwards AD (2018) Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND). Sci Rep 8:180–12. doi: 10.1038/s41598-018-22295-9

Walker SE, Wood TC, Cash D, Mesquita M, Williams SCR, Sandi C (2018) Alterations in brain microstructure in rats that develop abnormal aggression following peripubertal stress. Eur J Neurosci 79:840–15. doi: 10.1111/ejn.14061

2017

Crum, W.R., Sawiak, S.J., Chege, W., Cooper, J.D., Williams, S.C.R., Vernon, A.C., 2017.
Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: A longitudinal in vivo MRI study.
Brain Behavior and Immunity 1–10.

Westphal, R., Simmons, C., Mesquita, M.B., Wood, T.C., Williams, S.C.R., Vernon, A.C., Cash, D., 2017.
Characterization of the resting-state brain network topology in the 6-hydroxydopamine rat model of Parkinson’s disease.
PLoS ONE 12, e0172394–18.

Chesters R et al. (2017) 287. Neuroadaptations to Chronic Ketamine Exposure: A Parallel Human and Mouse MRI Imaging Study. Biological Psychiatry 81(10)S118. 

Crum et al. (2017) Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: A longitudinal in vivo MRI study. Brain, behavior, and immunity 63:50. 

Chesters R et al. (2017) 287. Neuroadaptations to Chronic Ketamine Exposure: A Parallel Human and Mouse MRI Imaging Study. Biological Psychiatry 81(10)S118. 

2016

 

Cash, D., Easton, A.C., Mesquita, M., Beech, J.S., Williams, S., Lloyd, A., Irving, A.J., Cramer, S.C., 2016. GSK249320,
A Monoclonal Antibody Against the Axon Outgrowth Inhibition Molecule Myelin-Associated Glycoprotein, Improves Outcome of Rodents with Experimental Stroke.
Journal of Neurology and Experimental Neuroscience 2, 28–33.

Duricki, D.A., Hutson, T.H., Kathe, C., Soleman, S., Gonzalez-Carter, D., Petruska, J.C., Shine, H.D., Chen, Q., Wood, T.C., Bernanos, M., Cash, D., Williams, S.C.R., Gage, F.H., Moon, L.D.F., 2016.
Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke.
Brain 139, 259–275.

Petrinovic, M.M., Hankov, G., Schroeter, A., Bruns, A., Rudin, M., Kienlin, von, M., Künnecke, B., Mueggler, T., 2016.
A novel anesthesia regime enables neurofunctional studies and imaging genetics across mouse strains.
Sci. Rep. 6, 1–12.

Tomimatsu, Y., Cash, D., Suzuki, M., Suzuki, K., Bernanos, M., Simmons, C., Williams, S.C.R., Kimura, H., 2016.
TAK-063, a phosphodiesterase 10A inhibitor, modulates neuronal activity in various brain regions in phMRI and EEG studies with and without ketamine challenge.
Neuroscience 339, 180–190.

Walker, T., Michaelides, C., Ekonomou, A., Geraki, K., Parkes, H.G., Suessmilch, M., Herlihy, A.H., Crum, W.R., So, P.-W., 2016. Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction. Aging (Albany NY) 8, 2488–2508.

Westphal, R., Sumiyoshi, A., Simmons, C., Mesquita, M., Wood, T.C., Williams, S.C.R., Vernon, A.C., Cash, D., 2016.
Characterization of gray matter atrophy following 6-hydroxydopamine lesion of the nigrostriatal system.
Neuroscience 334, 166–179. doi:10.1016/j.neuroscience.2016.07.046

Wood, T.C., Simmons, C., Hurley, S.A., Vernon, A.C., Torres, J., Dell’Acqua, F., Williams, S.C.R., Cash, D., 2016.
Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model.
PeerJ 4, e2632.

2015

Turkheimer, F.E., Leech, R., Expert, P., Lord, L.-D., Vernon, A.C., 2015.
The brain’s code and its canonical computational motifs. From sensory cortex to the default mode network: A multi-scale model of brain function in health and disease.
Neuroscience & Biobehavioral Reviews 55, 1–12.

Vernon, A.C., So, P.-W., Lythgoe, D.J., Chege, W., Cooper, J.D., Williams, S.C.R., Kapur, S., 2015.
Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic–polycytidylic acid in utero.
European Neuropsychopharmacology 25, 2210–2220.

2014

Finlay, C.J., Duty, S., Vernon, A.C., 2014.
Brain morphometry and the neurobiology of levodopa-induced dyskinesias: current knowledge and future potential for translational pre-clinical neuroimaging studies.
Front Neurol 5, 95.

Guidine, P.A.M., Cash, D., Drumond, L.E., de Souza e Rezende, G.H., Massensini, A.R., Williams, S.C.R., Moraes-Santos, T., Moraes, M.F.D., Mesquita, M.B.S., 2014.
Brainstem structures are primarily affected in an experimental model of severe scorpion envenomation.
Toxicological Sciences 137, 147–157.

Vernon, A.C., Crum, W.R., Lerch, J.P., Chege, W., Natesan, S., Modo, M., Cooper, J.D., Williams, S.C.R., Kapur, S., 2014.
Reduced Cortical Volume and Elevated Astrocyte Density in Rats Chronically Treated With Antipsychotic Drugs—Linking Magnetic Resonance Imaging Findings to Cellular Pathology.
Biological Psychiatry 75, 982–990.

2013, and earlier

Crum, W.R., Modo, M., Vernon, A.C., Barker, G.J., Williams, S.C.R., 2013.
Registration of challenging pre-clinical brain images.
Journal of Neuroscience Methods 216, 62–77.

Mesquita, M.B.S., Medeiros, D. de C., Cota, V.R., Richardson, M.P., Williams, S., Moraes, M.F.D., 2011.
Distinct temporal patterns of electrical stimulation influence neural recruitment during PTZ infusion: an fMRI study.
Prog. Biophys. Mol. Biol. 105, 109–118.

Vernon, A.C., Johansson, S.M., Modo, M.M., 2010.
Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson’s disease.
BMC Neurosci 11, 1.

Littlewood, C.L., Cash, D., Dixon, A.L., Dix, S.L., White, C.T., O’Neill, M.J., Tricklebank, M., Williams, S.C.R., 2006.
Using the BOLD MR signal to differentiate the stereoisomers of ketamine in the rat.
NeuroImage 32, 1733–1746.